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Tamoxifen Citrate Nolvadex Raw Powder CAS : 54965-24-1 PCT Bodybuilding

Author : johns Date : 11/21/2016 10:11:32 PM
 Specification:

 

1. Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, 4-hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a selective estrogen-receptor modulator. 

 

2. Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting.

3. Tamoxifen itself is a prodrug, having relatively little affinity for its target protein, the estrogen receptor. It is metabolized in the liver by the cytochrome P450 isoform CYP2D6 and CYP3A4 into active metabolites such as 4-hydroxytamoxifen (afimoxifene) and N-desmethyl-4-hydroxytamoxifen (endoxifen) which have 30-100 times more affinity with the estrogen receptor than tamoxifen itself. 

 

4. These active metabolites compete with estrogen in the body for binding to the estrogen receptor. In breast tissue, 4-hydroxytamoxifen acts as an estrogen receptor antagonist so that transcription of estrogen-responsive genes is inhibited.

5. 4-hydroxytamoxifen binds to estrogen receptors (ER), the ER/tamoxifen complex recruits other proteins known as co-repressors and then binds to DNA to modulate gene expression. Some of these proteins include NCoR and SMRT. Tamoxifen function can be regulated by a number of different variables including growth factors. 

 

6. Tamoxifen needs to block growth factor proteins such as ErbB2/HERbecause high levels of ErbB2 have been shown to occur in tamoxifen resistant cancers. Tamoxifen seems to require a protein PAX2 for its full anticancer effect. 

 

7. In the presence of high PAX2 expression, the tamoxifen/estrogen receptor complex is able to suppress the expression of the PRO-proliferative ERBB2 protein. In contrast, when AIB-1 expression is higher than PAX2, tamoxifen/estrogen receptor complex upregulates the expression of ERBB2 resulting in stimulation of breast cancer growth.

 

 

HOW TO TAKE NOLVADEX FOR PCT:

1. As an alternative to Clomid, which has been reported to have led to unwanted side effects such as visual disturbances in some users, Nolvadex can be employed. 

 

2. Nolvadex is a trade name for the drug Tamoxifen. Like Clomid, the half life of Nolvadex is relatively long enabling the user to implement a single daily dosing schedule.

 

3. Administration would start as per the timescales outlined above and the duration would be identical to that of Clomid.

 

Typically, for a moderate-heavy cycle, the following dosages would be used:


Day 1 - 100mg
Following 10 days - 60mg
Following 10 days - 40mg

 

1. Occasionally, heavier cycles containing perhaps Nandrolone (Deca) or Trenbolone which by definition are particularly suppressive of the HPTA, may require a slightly longer therapy. Likewise, more modest/shorter cycles may require lower dosages, perhaps dropping each by 20mg per day.

 

2. Some users like to use both Clomid and Nolvadex in their PCT in an attempt to cover all angles. 

An example of the dosages involved might be:

Day 1 - Clomid 200mg + Nolvadex 40mg
Following 10 days - Clomid 50mg + Nolvadex 20mg
Following 10 days - Clomid 50mg or Nolvadex 20mg

 

3. Of course, the examples provided are not set in stone and may be adjusted depending on the factors outlined above and individual variances